Anti-obesity effect of peel of Opuntia joconostle Web in high-fat-diet-induced obesity C57BL/6J mice

Obesity is directly associate to cancer, diabetes, cardiovascular diseases and hypertension producing severe complication of health economic costs in a global scale. This study aims validate the anti-obesity potential peel Opuntia joconostle hydroethanolic extract (XOCO) on obesity high-fat diet (HFD)-induced obese C57BL/6 mice. Therefore, phenolic compounds flavonoids profiles were investigated by colorimetric assay. We are using HFD induced mice after orally administered 200, 300 mg/kg XOC for 5 weeks. At end experimental period was determined body weight, food intake, serum biochemical parameters, fat organ histological analysis. research demonstrated that xoconostle had significantly amount flavonoids, showing highest level total compound (58.15 mg GAE/g extract) flavonoid content (59.12 CE/g extract). Treatment HFD-fed decreases adipogenesis, fat, absolute lipidemia, glucose levels, leptin, resistin, increases HDL-CHO levels adiponectin. In analysis showed inhibition deposition droplets liver. Findings indicated has effects obesity-induced effect may be due extract.